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-Structure paper
Title | Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 23, Page 3149-3153, Year 2013 |
Publish date | Apr 4, 2013 (structure data deposition date) |
Authors | Wang, X. / Magnuson, S. / Pastor, R. / Fan, E. / Hu, H. / Tsui, V. / Deng, W. / Murray, J. / Steffek, M. / Wallweber, H. ...Wang, X. / Magnuson, S. / Pastor, R. / Fan, E. / Hu, H. / Tsui, V. / Deng, W. / Murray, J. / Steffek, M. / Wallweber, H. / Moffat, J. / Drummond, J. / Chan, G. / Harstad, E. / Ebens, A.J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:23623490 |
Methods | X-ray diffraction |
Resolution | 1.954 - 2.082 Å |
Structure data | PDB-4k0y: PDB-4k18: PDB-4k1b: |
Chemicals | ChemComp-1OA: ChemComp-PO4: ChemComp-HOH: ChemComp-1OB: ChemComp-1OC: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / PIM-1 / kinase / Ser/Thr kinase / ATP-competitive / structure-based drug design / TRANSFERASE-TRANSFERASE INHIBITOR complex / kinase domain / phosphorylation |