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-Structure paper
Title | Discovery of Epigenetic Regulator I-Bet762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the Bet Bromodomains. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 7501-, Year 2013 |
Publish date | Sep 17, 2013 (structure data deposition date) |
Authors | Mirguet, O. / Gosmini, R. / Toum, J. / Clement, C. / Barnathan, M. / Brusq, J. / Mordaunt, J.E. / Grimes, R. / Crowe, M. / Pineau, O. ...Mirguet, O. / Gosmini, R. / Toum, J. / Clement, C. / Barnathan, M. / Brusq, J. / Mordaunt, J.E. / Grimes, R. / Crowe, M. / Pineau, O. / Ajakane, M. / Daugan, A. / Jeffrey, P. / Cutler, L. / Haynes, A. / Smithers, N. / Chung, C. / Bamborough, P. / Uings, I.J. / Lewis, T. / Witherington, J. / Parr, N. / Prinjha, R. / Nicodeme, E. |
External links | J. Med. Chem. / PubMed:24015967 |
Methods | X-ray diffraction |
Resolution | 1.55 - 1.87 Å |
Structure data | PDB-4c66: PDB-4c67: |
Chemicals | ChemComp-H4C: ChemComp-HOH: ChemComp-L5S: ChemComp-EDO: |
Source |
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Keywords | CELL CYCLE / TRANSCRIPTION REGULATION / INHIBITOR / EPIGENETIC READER / ANTAGONIST / HISTONE / EPIGENETIC READER BRD4 / BROMODOMAIN CONTAINING PROTEIN 4 |