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Title | Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036. |
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Journal, issue, pages | Cancer Cell, Vol. 19, Page 556-568, Year 2011 |
Publish date | Feb 18, 2011 (structure data deposition date) |
Authors | Chan, W.W. / Wise, S.C. / Kaufman, M.D. / Ahn, Y.M. / Ensinger, C.L. / Haack, T. / Hood, M.M. / Jones, J. / Lord, J.W. / Lu, W.P. ...Chan, W.W. / Wise, S.C. / Kaufman, M.D. / Ahn, Y.M. / Ensinger, C.L. / Haack, T. / Hood, M.M. / Jones, J. / Lord, J.W. / Lu, W.P. / Miller, D. / Patt, W.C. / Smith, B.D. / Petillo, P.A. / Rutkoski, T.J. / Telikepalli, H. / Vogeti, L. / Yao, T. / Chun, L. / Clark, R. / Evangelista, P. / Gavrilescu, L.C. / Lazarides, K. / Zaleskas, V.M. / Stewart, L.J. / Van Etten, R.A. / Flynn, D.L. |
External links | Cancer Cell / PubMed:21481795 |
Methods | X-ray diffraction |
Resolution | 1.82 - 2.3 Å |
Structure data | PDB-3qri: PDB-3qrj: PDB-3qrk: |
Chemicals | ChemComp-NA: ChemComp-919: ChemComp-HOH: ChemComp-9DP: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / ABL1 / KINASE / KINASE DOMAIN / TRANSFERASE-TRANSFERASE INHIBITOR complex / T315I / gatekeeper mutation |