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-Structure paper
Title | Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation. |
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Journal, issue, pages | Chem. Biol. Drug Des., Vol. 76, Page 154-163, Year 2010 |
Publish date | Apr 12, 2010 (structure data deposition date) |
![]() | Kutach, A.K. / Villasenor, A.G. / Lam, D. / Belunis, C. / Janson, C. / Lok, S. / Hong, L.N. / Liu, C.M. / Deval, J. / Novak, T.J. ...Kutach, A.K. / Villasenor, A.G. / Lam, D. / Belunis, C. / Janson, C. / Lok, S. / Hong, L.N. / Liu, C.M. / Deval, J. / Novak, T.J. / Barnett, J.W. / Chu, W. / Shaw, D. / Kuglstatter, A. |
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Methods | X-ray diffraction |
Resolution | 1.67 - 1.9 Å |
Structure data | ![]() PDB-3miy: ![]() PDB-3mj1: ![]() PDB-3mj2: |
Chemicals | ![]() ChemComp-B49: ![]() ChemComp-HOH: ![]() ChemComp-614: ![]() ChemComp-MJG: |
Source |
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![]() | TRANSFERASE / helix C-in / helix c-out / substrate blocking activation loop conformation |