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-Structure paper
Title | Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 1146-1158, Year 2010 |
Publish date | Aug 12, 2009 (structure data deposition date) |
Authors | Malamas, M.S. / Erdei, J. / Gunawan, I. / Turner, J. / Hu, Y. / Wagner, E. / Fan, K. / Chopra, R. / Olland, A. / Bard, J. ...Malamas, M.S. / Erdei, J. / Gunawan, I. / Turner, J. / Hu, Y. / Wagner, E. / Fan, K. / Chopra, R. / Olland, A. / Bard, J. / Jacobsen, S. / Magolda, R.L. / Pangalos, M. / Robichaud, A.J. |
External links | J. Med. Chem. / PubMed:19968289 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.246 Å |
Structure data | PDB-3ind: PDB-3ine: PDB-3inf: PDB-3inh: |
Chemicals | ChemComp-593: ChemComp-HOH: ChemComp-X17: ChemComp-X45: ChemComp-569: |
Source |
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Keywords | HYDROLASE / Bace1 / xray / inhibitor / Alternative splicing / Aspartyl protease / Disulfide bond / Glycoprotein / Membrane / Polymorphism / Protease / Transmembrane / Zymogen |