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Structure paper

TitleStructural insights into parasite EIF4E binding specificity for m7G and m2,2,7G mRNA cap.
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 31336-31349, Year 2009
Publish dateJun 20, 2009 (structure data deposition date)
AuthorsLiu, W. / Zhao, R. / McFarland, C. / Kieft, J. / Niedzwiecka, A. / Jankowska-Anyszka, M. / Stepinski, J. / Darzynkiewicz, E. / Jones, D.N. / Davis, R.E.
External linksJ. Biol. Chem. / PubMed:19710013
MethodsX-ray diffraction
Resolution1.8 - 2.1 Å
Structure data

PDB-3hxg:
Crystal structure of Schistsome eIF4E complexed with m7GpppA and 4E-BP
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3hxi:
Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-GTA:
P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-GTG:
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE

Source
  • schistosoma mansoni (invertebrata)
  • homo sapiens (human)
KeywordsTRANSLATION / protein-mRNA cap complex / Acetylation / Phosphoprotein / Protein synthesis inhibitor / Translation regulation

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