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-Structure paper
Title | Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. |
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Journal, issue, pages | Nat. Biotechnol., Vol. 28, Page 63-70, Year 2010 |
Publish date | Feb 3, 2009 (structure data deposition date) |
Authors | Burgin, A.B. / Magnusson, O.T. / Singh, J. / Witte, P. / Staker, B.L. / Bjornsson, J.M. / Thorsteinsdottir, M. / Hrafnsdottir, S. / Hagen, T. / Kiselyov, A.S. ...Burgin, A.B. / Magnusson, O.T. / Singh, J. / Witte, P. / Staker, B.L. / Bjornsson, J.M. / Thorsteinsdottir, M. / Hrafnsdottir, S. / Hagen, T. / Kiselyov, A.S. / Stewart, L.J. / Gurney, M.E. |
External links | Nat. Biotechnol. / PubMed:20037581 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.65 Å |
Structure data | PDB-3g45: PDB-3g4g: PDB-3g4i: PDB-3g4k: PDB-3g4l: PDB-3g58: PDB-3iad: |
Chemicals | ChemComp-ZN: ChemComp-MG: ChemComp-988: ChemComp-HOH: ChemComp-CA: ChemComp-D71: ChemComp-SO4: ChemComp-EOH: ChemComp-ROL: ChemComp-EDO: ChemComp-ROF: ChemComp-15X: ChemComp-EPE: |
Source |
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Keywords | HYDROLASE / phosphodiesterase / Alternative splicing / cAMP / Phosphoprotein / Polymorphism / PDE4D / UCR2 / Cytoplasm / Cytoskeleton / Membrane / Metal-binding / Allosteric modulatory / inhibitor |