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-Structure paper
Title | Fragment-based discovery of JAK-2 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 279-282, Year 2009 |
Publish date | Aug 14, 2008 (structure data deposition date) |
Authors | Antonysamy, S. / Hirst, G. / Park, F. / Sprengeler, P. / Stappenbeck, F. / Steensma, R. / Wilson, M. / Wong, M. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19019674 |
Methods | X-ray diffraction |
Resolution | 1.8 - 1.922 Å |
Structure data | PDB-3e62: PDB-3e63: PDB-3e64: |
Chemicals | ChemComp-5B1: ChemComp-HOH: ChemComp-5B2: ChemComp-5B3: |
Source |
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Keywords | TRANSFERASE / DRUG DISCOVERY / JAK2 / FRAGMENT BASED / ATP-binding / Disease mutation / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Proto-oncogene / SH2 domain / Tyrosine-protein kinase |