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TitleStructural Basis of Substrate Recognition in Thiopurine S-Methyltransferase
Journal, issue, pagesBiochemistry, Vol. 47 (23), 6216 6225, 2008. 10.1021/bi800102x, Page 6216-6225, Year 2008
Publish dateNov 26, 2007 (structure data deposition date)
AuthorsPeng, Y. / Feng, Q. / Wilk, D. / Adjei, A.A. / Salavaggione, O.E. / Weinshilboum, R.M. / Yee, V.C.
External linksBiochemistry / PubMed:18484748
MethodsX-ray diffraction
Resolution1.8 - 2 Å
Structure data

PDB-3bgd:
Thiopurine S-Methyltransferase
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3bgi:
Thiopurine S-Methyltransferase
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-PM6:
9H-purine-6-thiol / medication*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsTRANSFERASE / Methyltransferase / Cytoplasm / S-adenosyl-L-methionine

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