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-Structure paper
Title | Novel Thienopyrimidine and Thiazolopyrimidine Kinase Inhibitors with Activity Against Tie-2 in Vitro and in Vivo. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 6670-, Year 2009 |
Publish date | Aug 18, 2009 (structure data deposition date) |
Authors | Luke, R.W. / Ballard, P. / Buttar, D. / Campbell, L. / Curwen, J. / Emery, S.C. / Griffen, A.M. / Hassall, L. / Hayter, B.R. / Jones, C.D. ...Luke, R.W. / Ballard, P. / Buttar, D. / Campbell, L. / Curwen, J. / Emery, S.C. / Griffen, A.M. / Hassall, L. / Hayter, B.R. / Jones, C.D. / Mccoull, W. / Mellor, M. / Swain, M.L. / Tucker, J.A. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19854647 |
Methods | X-ray diffraction |
Resolution | 2.95 Å |
Structure data | PDB-2wqb: |
Chemicals | ChemComp-QQ1: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / PHOSPHOPROTEIN / KINASE / RECEPTOR / ONCOLOGY / ATP-BINDING / GLYCOPROTEIN / TYROSINE-PROTEIN KINASE / PHOSPHOTRANSFERASE / NUCLEOTIDE-BINDING / DISEASE MUTATION / THIAZOLOPYRIMIDINE |