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-Structure paper
Title | Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. |
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Journal, issue, pages | J. Med. Chem., Vol. 51, Page 7486-7494, Year 2008 |
Publish date | Mar 6, 2007 (structure data deposition date) |
Authors | Humljan, J. / Kotnik, M. / Contreras-Martel, C. / Blanot, D. / Urleb, U. / Dessen, A. / Solmajer, T. / Gobec, S. |
External links | J. Med. Chem. / PubMed:19007109 |
Methods | X-ray diffraction |
Resolution | 1.88 - 2.5 Å |
Structure data | PDB-2uuo: PDB-2uup: PDB-2vtd: PDB-2vte: |
Chemicals | ChemComp-SO4: ChemComp-LK3: ChemComp-HOH: ChemComp-LK4: ChemComp-LKM: ChemComp-IK4: |
Source |
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Keywords | LIGASE / MURD-INHIBITOR COMPLEX / PEPTIDOGLYCAN SYNTHESIS / CELL WALL / CELL SHAPE / CELL CYCLE / NUCLEOTIDE-BINDING / SULFONAMIDE INHIBITOR / MURD LIGASE / ATP-BINDING / CELL DIVISION / CYTOPLASM / CELL WALL BIOGENESIS/DEGRADATION |