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-Structure paper
Title | Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex |
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Journal, issue, pages | Biochemistry, Vol. 46, Page 14878-14888, Year 2007 |
Publish date | Oct 5, 2007 (structure data deposition date) |
Authors | Krahn, J.M. / Jackson, M.R. / DeRose, E.F. / Howell, E.E. / London, R.E. |
External links | Biochemistry / PubMed:18052202 |
Methods | X-ray diffraction |
Resolution | 0.96 - 1.9 Å |
Structure data | PDB-2rh2: PDB-2rk1: PDB-2rk2: |
Chemicals | ChemComp-MRD: ChemComp-HOH: ChemComp-DHF: ChemComp-NAP: |
Source |
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Keywords | OXIDOREDUCTASE / FOLATE METABOLISM / PLASMID-ENCODED R67 DHFR / TMP-RESISTANT DHFR / Antibiotic resistance / Methotrexate resistance / NADP / One-carbon metabolism / Trimethoprim resistance / dihydrofolate / asymmetric ligand binding / Plasmid |