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-Structure paper
Title | The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 105, Page 2070-, Year 2008 |
Publish date | Jul 1, 2007 (structure data deposition date) |
Authors | Yun, C.-H. / Mengwasser, K.E. / Toms, A.V. / Woo, M.S. / Greulich, H. / Wong, K. / Meyerson, M. / Eck, M.J. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:18227510 |
Methods | X-ray diffraction |
Resolution | 3.05 - 3.5 Å |
Structure data | PDB-2jit: PDB-2jiu: PDB-2jiv: |
Chemicals | ChemComp-HOH: ChemComp-AEE: ChemComp-HKI: ChemComp-CL: |
Source |
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Keywords | TRANSFERASE / EGFR / T790M / KINASE / RECEPTOR / CELL CYCLE / PHOSPHORYLATION / DISEASE MUTATION / NUCLEOTIDE-BINDING / TYROSINE-PROTEIN KINASE / ANTI-ONCOGENE / EPIDERMAL GROWTH FACTOR / ATP-BINDING / ALTERNATIVE SPLICING / AEE788 / TRANSMEMBRANE / HKI272 / HKI-272 |