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TitleToward rational design of ribonuclease inhibitors: high-resolution crystal structure of a ribonuclease A complex with a potent 3',5'-pyrophosphate-linked dinucleotide inhibitor.
Journal, issue, pagesBiochemistry, Vol. 38, Page 10287-10297, Year 1999
Publish dateMay 12, 1999 (structure data deposition date)
AuthorsLeonidas, D.D. / Shapiro, R. / Irons, L.I. / Russo, N. / Acharya, K.R.
External linksBiochemistry / PubMed:10441122
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-1qhc:
CRYSTAL STRUCTURE OF RIBONUCLEASE A IN COMPLEX WITH 5'-PHOSPHO-2'-DEOXYURIDINE-3'-PYROPHOSPHATE ADENOSINE-3'-PHOSPHATE
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-PUA:
ADENYLATE-3'-PHOSPHATE-[[2'-DEOXY-URIDINE-5'-PHOSPHATE]-3'-PHOSPHATE]

ChemComp-HOH:
WATER

Source
  • bos taurus (cattle)
KeywordsHYDROLASE / RIBONUCLEASE / ENDONUCLEASE / NUCLEOTIDE INHIBITOR

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