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TitleSolution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope.
Journal, issue, pagesJ. Mol. Biol., Vol. 314, Page 1147-1156, Year 2001
Publish dateJul 19, 2001 (structure data deposition date)
AuthorsPires, J.R. / Taha-Nejad, F. / Toepert, F. / Ast, T. / Hoffmuller, U. / Schneider-Mergener, J. / Kuhne, R. / Macias, M.J. / Oschkinat, H.
External linksJ. Mol. Biol. / PubMed:11743730
MethodsNMR (solution)
Structure data

PDB-1jmq:
YAP65 (L30K mutant) WW domain in Complex with GTPPPPYTVG peptide
Method: SOLUTION NMR

PDB-1k9q:
YAP65 WW domain complexed to N-(n-octyl)-GPPPY-NH2
Method: SOLUTION NMR

PDB-1k9r:
YAP65 WW domain complexed to Acetyl-PLPPY
Method: SOLUTION NMR

Chemicals

ChemComp-OCT:
N-OCTANE

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / WW domain / polyproline ligand / YAP65 mutant / YAP65 / beta-sheet proteins / ligands / proline-rich peptides

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