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Structure paper

TitleStructural basis of chiral wrap and T-segment capture by Escherichia coli DNA gyrase
Journal, issue, pagesProceedings of the National Academy of Sciences USA, Year 2024
Publish dateAug 13, 2024 (structure data deposition date)
AuthorsMichalczyk E / Pakosz-Stepien Z / Liston JD / Gittins O / Pabis M / Heddle JG / Ghilarov D
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.6 Å
Structure data

51339

9ggq

EMDB-51339, PDB-9ggq:
E.coli gyrase holocomplex with cleaved chirally wrapped 217 bp DNA fragment and moxifloxacin
Method: EM (single particle) / Resolution: 2.6 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-MFX:
1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid / antibiotic*YM

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • escherichia phage mu (virus)
KeywordsISOMERASE / DNA gyrase / type II topoisomerase / moxifloxacin / DNA crossover

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