Title | Human polymerase theta helicase positions DNA microhomologies for double-strand break repair |
---|
Journal, issue, pages | To Be Published |
---|
Publish date | Apr 19, 2024 (structure data deposition date) |
---|
Authors | Zerio CJ / Bai Y / Sosa-Alvarado BA / Guzi T / Lander GC |
---|
External links | Search PubMed |
---|
Methods | EM (single particle) |
---|
Resolution | 3.3 - 3.6 Å |
---|
Structure data | EMDB-44534, PDB-9bh6: Human DNA polymerase theta helicase domain tetramer in the apo form Method: EM (single particle) / Resolution: 3.3 Å EMDB-44535, PDB-9bh7: Human DNA polymerase theta helicase domain dimer in the apo form Method: EM (single particle) / Resolution: 3.5 Å EMDB-44536, PDB-9bh8: Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology searching conformation Method: EM (single particle) / Resolution: 3.6 Å EMDB-44537, PDB-9bh9: Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology aligning conformation Method: EM (single particle) / Resolution: 3.5 Å EMDB-44538, PDB-9bha: Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology annealed conformation Method: EM (single particle) / Resolution: 3.5 Å |
---|
Source | - homo sapiens (human)
- synthetic construct (others)
|
---|
Keywords | DNA BINDING PROTEIN / DNA repair / TMEJ / MMEJ |
---|