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TitleArchitecture of the human mTORC2 core complex.
Journal, issue, pagesElife, Vol. 7, Year 2018
Publish dateFeb 9, 2018
AuthorsEdward Stuttfeld / Christopher Hs Aylett / Stefan Imseng / Daniel Boehringer / Alain Scaiola / Evelyn Sauer / Michael N Hall / Timm Maier / Nenad Ban /
PubMed AbstractThe mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 ...The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.
External linksElife / PubMed:29424687 / PubMed Central
MethodsEM (single particle)
Resolution6.2 - 7.4 Å
Structure data

EMDB-3927:
Architecture of the human mTORC2 core complex (C2)
Method: EM (single particle) / Resolution: 7.4 Å

EMDB-3928:
Human mTORC2 core complex accessory factors
Method: EM (single particle) / Resolution: 6.2 Å

Source
  • Homo sapiens (human)

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