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TitleCryo-EM structures of the human INO80 chromatin-remodeling complex.
Journal, issue, pagesNat Struct Mol Biol, Vol. 25, Issue 1, Page 37-44, Year 2018
Publish dateDec 4, 2017
AuthorsRicardo J Aramayo / Oliver Willhoft / Rafael Ayala / Rohan Bythell-Douglas / Dale B Wigley / Xiaodong Zhang /
PubMed AbstractAccess to chromatin for processes such as transcription and DNA repair requires the sliding of nucleosomes along DNA. This process is aided by chromatin-remodeling complexes, such as the multisubunit ...Access to chromatin for processes such as transcription and DNA repair requires the sliding of nucleosomes along DNA. This process is aided by chromatin-remodeling complexes, such as the multisubunit INO80 chromatin-remodeling complex. Here we present cryo-EM structures of the active core complex of human INO80 at 9.6 Å, with portions at 4.1-Å resolution, and reconstructions of combinations of subunits. Together, these structures reveal the architecture of the INO80 complex, including Ino80 and actin-related proteins, which is assembled around a single RUVBL1 (Tip49a) and RUVBL2 (Tip49b) AAA+ heterohexamer. An unusual spoked-wheel structural domain of the Ino80 subunit is engulfed by this heterohexamer; both, in combination, form the core of the complex. We also identify a cleft in RUVBL1 and RUVBL2, which forms a major interaction site for partner proteins and probably communicates these interactions to its nucleotide-binding sites.
External linksNat Struct Mol Biol / PubMed:29323271 / PubMed Central
MethodsEM (single particle)
Resolution4.06 - 11.5 Å
Structure data

EMDB-3772:
hINO80 core complex
Method: EM (single particle) / Resolution: 9.6 Å

3773

5oaf

EMDB-3773: High resolution INO80 core complex
PDB-5oaf: Human Rvb1/Rvb2 heterohexamer in INO80 complex
Method: EM (single particle) / Resolution: 4.06 Å

EMDB-3774:
Cryo-EM structure of a human INO80 sub-complex (RuvBL1/2, Ino80)
Method: EM (single particle) / Resolution: 11.5 Å

EMDB-3775:
Cryo-EM structure of a human INO80 sub-complex (RuvBL1/2, Ino80, Arp5, Ies6, Ies2)
Method: EM (single particle) / Resolution: 8.4 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / Chromatin remodelling complex

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