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-Structure paper
Title | Expanding the Huntingtons disease research toolbox; validated huntingtin subdomain constructs for biochemical and structural investigation of the huntingtin protein |
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Journal, issue, pages | Biorxiv, Year 2022 |
Publish date | Nov 3, 2022 (structure data deposition date) |
Authors | Alteen MG / Deme JC / Alvarez CP / Loppnau P / Hutchinson A / Seitova A / Chandrasekaran R / Silva Ramos E / Secker C / Alqazzaz M ...Alteen MG / Deme JC / Alvarez CP / Loppnau P / Hutchinson A / Seitova A / Chandrasekaran R / Silva Ramos E / Secker C / Alqazzaz M / Wanker EE / Lea SM / Arrowsmith CH / Harding RJ |
External links | Biorxiv / Search PubMed |
Methods | EM (single particle) |
Resolution | 3.2 - 3.3 Å |
Structure data | EMDB-28766: Huntingtin C-HEAT domain in complex with HAP40 EMDB-28767: Full-length Huntingtin-HAP40 complex from subdomain fragments |
Source |
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