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-Structure paper
Title | The structure of a virus-encoded nucleosome. |
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Journal, issue, pages | Nat Struct Mol Biol, Vol. 28, Issue 5, Page 413-417, Year 2021 |
Publish date | Apr 29, 2021 |
Authors | Marco Igor Valencia-Sánchez / Stephen Abini-Agbomson / Miao Wang / Rachel Lee / Nikita Vasilyev / Jenny Zhang / Pablo De Ioannes / Bernard La Scola / Paul Talbert / Steve Henikoff / Evgeny Nudler / Albert Erives / Karim-Jean Armache / |
PubMed Abstract | Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to ...Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes. |
External links | Nat Struct Mol Biol / PubMed:33927388 / PubMed Central |
Methods | EM (single particle) |
Resolution | 3.4 - 4.5 Å |
Structure data | EMDB-23529, PDB-7lv8: EMDB-23530, PDB-7lv9: |
Source |
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Keywords | STRUCTURAL PROTEIN/DNA / STRUCTURAL PROTEIN / STRUCTURAL PROTEIN-DNA complex |