Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Untangling desmosomal knots with electron tomography.
Journal, issue, pages	Science, Vol. 302, Issue 5642, Page 109-113, Year 2003
Publish date	Oct 3, 2003
Authors	Wanzhong He / Pamela Cowin / David L Stokes /
PubMed Abstract	Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion ...Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion remain controversial. We used electron tomography of plastic sections from neonatal mouse skin to visualize the organization of desmosomes in situ. The resulting three-dimensional maps reveal individual cadherin molecules forming discrete groups and interacting through their tips. Fitting of an x-ray crystal structure for C-cadherin to these maps is consistent with a flexible intermolecular interface mediated by an exchange of amino-terminal tryptophans. This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction.
External links	Science / PubMed:14526082
Methods	EM (tomography)
Resolution	20.0 - 30.0 Å
Structure data	1051 1q55 1q5a 1q5b 1q5c EMDB-1051: Untangling desmosomal knots with electron tomography. PDB-1q55: W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5a: S-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5b: lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5c: S-S-lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography Method: EM (tomography) / Resolution: 30.0 Å 1052 1q55 1q5a 1q5b 1q5c EMDB-1052: Untangling desmosomal knots with electron tomography. PDB-1q55: W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5a: S-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5b: lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5c: S-S-lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography Method: EM (tomography) / Resolution: 30.0 Å 1053 1q5b EMDB-1053: Untangling desmosomal knots with electron tomography. PDB-1q5b: lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography Method: EM (tomography) / Resolution: 20.0 Å
Chemicals	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose ChemComp-NDG: 2-acetamido-2-deoxy-alpha-D-glucopyranose ChemComp-CA: Unknown entry
Source	mus musculus (house mouse)
Keywords	STRUCTURAL PROTEIN / CADHERIN; TRANS INTERACTION; DESMOSOME; JUNCTION; ADHESION