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Structure paper

TitleForestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Journal, issue, pagesTo be Published
Publish dateDec 9, 2011 (structure data deposition date)
AuthorsWan, Z.L. / Hua, Q.X. / Wickramasinghe, N.P. / Huang, K. / Petkova, A.T. / Hu, S.Q. / Phillips, N.B. / Yeh, I.J. / Whittake, J. / Ismail-Beigi, F. ...Wan, Z.L. / Hua, Q.X. / Wickramasinghe, N.P. / Huang, K. / Petkova, A.T. / Hu, S.Q. / Phillips, N.B. / Yeh, I.J. / Whittake, J. / Ismail-Beigi, F. / Katsoyyannis, P.G. / Tycko, R. / Weiss, M.A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2 - 2.2 Å
Structure data

PDB-3v19:
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3v1g:
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-IPH:
PHENOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE / zinc-binding site / long-acting insulin analog / receptor binding / protein engineering / insulin fibrillation / receptor binding protein engineering

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