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TitleStructure-based design of seed-competent proteomimetic macrocycles derived from 4R tauopathic folds
Journal, issue, pagesTo Be Published
Publish dateMar 18, 2024 (structure data deposition date)
AuthorsXu X / Angera JI / Rajewski HB / Jiang W / Del Valle RJ
External linksSearch PubMed
MethodsEM (helical sym.)
Resolution2.95 - 3.2 Å
Structure data

44133

9b3a

EMDB-44133, PDB-9b3a:
filament of type 1 KD-mxyl miniature tau macrocycle derived from 4R tauopathic fold
Method: EM (helical sym.) / Resolution: 3.2 Å

44134

9b3c

EMDB-44134, PDB-9b3c:
type 2 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold
Method: EM (helical sym.) / Resolution: 2.95 Å

47002

9dme

EMDB-47002, PDB-9dme:
Type 3 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold
Method: EM (helical sym.) / Resolution: 3.2 Å

Chemicals

ChemComp-NH2:
AMINO GROUP

ChemComp-8VH:
1,3-dimethylbenzene

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / tauopathies / neurodegenerative disorders / seed-competent miniature tau macrocycle

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