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TitleMemantine Inhibits Calcium-Permeable AMPA Receptors
Journal, issue, pagesTo Be Published
Publish dateOct 25, 2024 (structure data deposition date)
AuthorsCarrillo E / Montano Romero A / Gonzalez CU / Turcu AL / Chen S / Chen H / Pan H / Vazquez S / Twomey EC / Jayarman V
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.7 - 4.3 Å
Structure data

47520

9e4y

EMDB-47520, PDB-9e4y:
GluA2-gamma2 complex bound to memantine, glutamate, and cyclothiazide
Method: EM (single particle) / Resolution: 4.3 Å

47521

9e4z

EMDB-47521, PDB-9e4z:
GluA2-gamma2 complex bound glutamate and cyclothiazide
Method: EM (single particle) / Resolution: 3.7 Å

Chemicals

ChemComp-377:
Memantine / medication*YM

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-CYZ:
CYCLOTHIAZIDE

Source
  • rattus norvegicus (Norway rat)
  • mus musculus (house mouse)
KeywordsTRANSPORT PROTEIN / ligand-gated ion channel / ionotropic glutamate receptor / ampa receptor / ion channel

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