タイトル | Discovery of YTHDF2 Ligands by Fragment-Based Design |
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ジャーナル・号・ページ | Acs Bio Med Chem Au, Year 2025 |
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掲載日 | 2025年3月10日 (構造データの登録日) |
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著者 | Invernizzi, A. / Nai, F. / Bedi, R.K. / Vargas-Rosales, P.A. / Li, Y. / Bochenkova, E. / Herok, M. / Zalesak, F. / Caflisch, A. |
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リンク | Acs Bio Med Chem Au / PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.7 - 2.46 Å |
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構造データ | PDB-9qel: Crystal structure of YTHDF2 in complex with compound 4 (AI-DF2-13) 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-9qem: Crystal structure of YTHDF2 in complex with compound 3 (AI-DF2-11) 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-9qeo: Crystal structure of YTHDF2 in complex with compound 5 (AI-DF2-36) 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-9qfl: Crystal structure of YTHDF2 in complex with compound 15 (AI-DF2-68) 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-9qiu: Crystal structure of YTHDF2 in complex with compound 13 (AI-DF2-56) 手法: X-RAY DIFFRACTION / 解像度: 2.46 Å |
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化合物 | PDB-1i56: SOLUTION STRUCTURE OF CA2+-BOUND STATE OF CANINE MILK LYSOZYME
PDB-1i6e: SOLUTION STRUCTURE OF THE FUNCTIONAL DOMAIN OF PARACOCCUS DENITRIFICANS CYTOCHROME C552 IN THE OXIDIZED STATE
PDB-1i5u: SOLUTION STRUCTURE OF CYTOCHROME B5 TRIPLE MUTANT (E48A/E56A/D60A)
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由来 | homo sapiens (ヒト)
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キーワード | RNA BINDING PROTEIN / Inhibitor / m6A reader |
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