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-Structure paper
Title | Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides |
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Journal, issue, pages | To Be Published |
Publish date | Jul 3, 2025 (structure data deposition date) |
![]() | Ghosh ND / Freyer N / Petrychenko V / Schwarzer AC / Peng BZ / Samatova E / Kothe C / Schmidt M / Peske F / Politi A ...Ghosh ND / Freyer N / Petrychenko V / Schwarzer AC / Peng BZ / Samatova E / Kothe C / Schmidt M / Peske F / Politi A / Urlaub H / Fischer N / Rodnina MV / Wohlgemuth I |
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Methods | EM (single particle) |
Resolution | 2.53 - 9.5 Å |
Structure data | EMDB-54253: Structure of 70S ribosome-EF-G(P610L)-GDP-Pi-apramycin complex with tRNAs in hybrid state 1 (H1- EF-G(P610L)-GDP-Pi) ![]() EMDB-55123: Structure of 70S ribosome-apramycin complex with tRNAs in classic state (C) ![]() EMDB-55124: Structure of 70S ribosome-apramycin complex with tRNAs in hybrid state 1 (H1) ![]() EMDB-55125: Structure of 70S ribosome-apramycin complex with tRNAs in hybrid state 2 (H2) |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-ZN: ![]() ChemComp-NA: ![]() ChemComp-AM2: ![]() ChemComp-PO4: ![]() ChemComp-GDP: |
Source |
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![]() | RIBOSOME / EF-G / robosome / 70S / apramycin / translocation / mutation |