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Title | Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures |
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Journal, issue, pages | Chem Sci, Vol. 13, Page 2985-2991, Year 2022 |
Publish date | Sep 21, 2020 (structure data deposition date) |
![]() | Wood, T.M. / Zeronian, M.R. / Buijs, N. / Bertheussen, K. / Abedian, H.K. / Johnson, A.V. / Pearce, N.M. / Lutz, M. / Kemmink, J. / Seirsma, T. ...Wood, T.M. / Zeronian, M.R. / Buijs, N. / Bertheussen, K. / Abedian, H.K. / Johnson, A.V. / Pearce, N.M. / Lutz, M. / Kemmink, J. / Seirsma, T. / Hamoen, L.W. / Janssen, B.J.C. / Martin, N.I. |
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Methods | X-ray diffraction |
Resolution | 1.04 - 1.135 Å |
Structure data | ![]() PDB-7ag5: ![]() PDB-7any: |
Chemicals | ![]() ChemComp-CA: ![]() ChemComp-RDZ: ![]() ChemComp-9GE: ![]() ChemComp-HOH: ![]() ChemComp-CL: ![]() ChemComp-CD: ![]() ChemComp-NA: |
Source |
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![]() | ANTIBIOTIC / Calcium-dependent antibiotic / Bacterial cell wall biosynthesis inhibitor / Lipopeptide antibiotic |