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TitleTargeting Plasmodium falciparum GRP78: nucleoside analogues as agents against the malaria chaperone
Journal, issue, pagesFrontiers in Molecular Bioscience, Year 2022
Publish dateMay 27, 2022 (structure data deposition date)
AuthorsMrozek, A. / Park, H.W.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-8d1w:
Crystal structure of Plasmodium falciparum GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-HFY:
8-{[(2-chlorophenyl)methyl]amino}adenosine

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsCHAPERONE / ATPase

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