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-Structure paper
Title | Crystal structures of quinone reductase 2 bound to antimalarial drugs reveal conformational change upon reduction |
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Journal, issue, pages | J. Biol. Chem., Year 2013 |
Publish date | Jun 4, 2012 (structure data deposition date) |
Authors | Leung, K.K. / Shilton, B.H. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 1.2 - 1.401 Å |
Structure data | PDB-4fgj: PDB-4fgk: PDB-4fgl: |
Chemicals | ChemComp-ZN: ChemComp-FAD: ChemComp-1PQ: ChemComp-GOL: ChemComp-HOH: ChemComp-0TX: ChemComp-CLQ: |
Source |
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Keywords | oxidoreductase/oxidoreductase inhibitor / primaquine / FMN reductase superfamily / metallo-flavoprotein / Rossmann fold / two-electron reduction of quinones to hydroquinones / FAD binding / Zn binding / cytosol / oxidoreductase-oxidoreductase inhibitor complex / chloroquine / FMN reductase superfamily (conserved domain database) |