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Structure paper

TitleStable human IgG antibody therapeutics with native framework structure
Journal, issue, pagesTo Be Published
Publish dateOct 27, 2017 (structure data deposition date)
AuthorsChristie, M. / Rouet, R. / Nevoltris, D. / Langley, D. / Schofield, P. / Fabri, L. / Tingey, K. / Lowe, D. / Jermutus, L. / Christ, D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.55 - 2.7 Å
Structure data

PDB-6bft:
Structure of Bevacizumab Fab mutant in complex with VEGF
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-6bgt:
Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Avastin / antibody / TRANSFERASE/IMMUNE SYSTEM / Herceptin / TRANSFERASE-IMMUNE SYSTEM complex

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