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TitleThe Crystal Structure of Type a Influenza Virus Neuraminidase of the N6 Subtype Reveals the Existence of Two Separate Neu5Ac Binding Sites
Journal, issue, pagesTo be Published
Publish dateJun 24, 2004 (structure data deposition date)
AuthorsRudino-Pinera, E. / Tunnah, P. / Crennell, S.J. / Webster, R.G. / Laver, W.G. / Garman, E.F.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2 - 2.15 Å
Structure data

PDB-1w1x:
Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 277 K.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1w20:
Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 291 K
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

PDB-1w21:
Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 43 hours at 291 K.
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

PDB-2cml:
Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-SIA:
N-acetyl-alpha-neuraminic acid

ChemComp-CA:
Unknown entry

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-BMA:
beta-D-mannopyranose

ChemComp-HOH:
WATER

ChemComp-ZMR:
ZANAMIVIR / medication*YM

Source
  • influenza a virus
  • influenza virus type a
KeywordsHYDROLASE / INFLUENZA TYPE A / NEURAMINIDASE / HB SITE / SIALIC ACID / SUBTYPE N6 / GLYCOSIDASE / TRANSMEMBRANE

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