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Structure paper

TitleStructural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate
Journal, issue, pagesAcs Catalysis, Vol. 11, Page 14956-14966, Year 2021
Publish dateSep 27, 2021 (structure data deposition date)
AuthorsWander, R. / Kaminski, A.M. / Wang, Z. / Stancanelli, E. / Xu, Y. / Pagadala, V. / Li, J. / Krahn, J.M. / Pham, T.Q. / Liu, J. / Pedersen, L.C.
External linksAcs Catalysis / Search PubMed
MethodsX-ray diffraction
Resolution2.75 - 2.9 Å
Structure data

PDB-7scd:
Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-1 octasaccharide substrate and co-factor product PAP
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-7sce:
Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-2 octasaccharide substrate and co-factor product PAP
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-A3P:
ADENOSINE-3'-5'-DIPHOSPHATE

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • homo sapiens (human)
KeywordsTRANSFERASE/SUBSTRATE / sulfotransferase / heparan sulfate / oligosaccharide / complex / TRANSFERASE / TRANSFERASE-SUBSTRATE complex

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