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TitleTamsulosin inhibits the release of Chloride ion through wedging into a novel allosteric site of TMEM16A
Journal, issue, pagesTo Be Published
Publish dateDec 26, 2023 (structure data deposition date)
AuthorsLi HL / Li SL / Li S
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.93 Å
Structure data

38456

8xlr

EMDB-38456, PDB-8xlr:
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Method: EM (single particle) / Resolution: 2.93 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-C14:
TETRADECANE

ChemComp-CA:
Unknown entry

ChemComp-JGX:
Tamsulosin

ChemComp-HEX:
HEXANE

Source
  • mus musculus (house mouse)
KeywordsLIPID BINDING PROTEIN / Inhibitor / Modulator / Complex / Ion channel

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