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TitleTargeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Journal, issue, pagesFront Immunol, Vol. 11, Page 1228-, Year 2020
Publish dateJul 27, 2020 (structure data deposition date)
AuthorsTu, W.J. / McCuaig, R.D. / Tan, A.H.Y. / Hardy, K. / Seddiki, N. / Ali, S. / Dahlstrom, J.E. / Bean, E.G. / Dunn, J. / Forwood, J. ...Tu, W.J. / McCuaig, R.D. / Tan, A.H.Y. / Hardy, K. / Seddiki, N. / Ali, S. / Dahlstrom, J.E. / Bean, E.G. / Dunn, J. / Forwood, J. / Tsimbalyuk, S. / Smith, K. / Yip, D. / Malik, L. / Prasanna, T. / Milburn, P. / Rao, S.
External linksFront Immunol / Search PubMed
MethodsX-ray diffraction
Resolution1.96 - 2.06 Å
Structure data

PDB-7jjm:
Crystal structure of Importin alpha 2 in complex with LSD1 NLS
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-7jk7:
Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsPROTEIN TRANSPORT / Importin Demethylase / Importin alpha demethylase nuclear localisation

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