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Structure paper

TitleUnveiling Conformational Selective Regulation of the Norepinephrine Transporter
Journal, issue, pagesTo Be Published
Publish dateNov 3, 2024 (structure data deposition date)
AuthorsZhang H / Xu EH / Jiang Y
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.44 Å
Structure data

62267

9kda

EMDB-62267, PDB-9kda:
Cryo-EM structure of lipid-mediated dimer of human norepinephrine transporter NET in the presence of the antidepressant vilazodone in an inward-open state at resolution of 2.44 angstrom.
Method: EM (single particle) / Resolution: 2.44 Å

Chemicals

ChemComp-YG7:
5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide

ChemComp-CLR:
CHOLESTEROL

PDB-1efm:
STRUCTURE OF THE GDP DOMAIN OF EF-TU AND LOCATION OF THE AMINO ACIDS HOMOLOGOUS TO RAS ONCOGENE PROTEINS

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTON TRANSPORT / Complex

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