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TitleTrispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
Journal, issue, pagesTo Be Published
Publish dateMar 9, 2019 (structure data deposition date)
AuthorsWu, L. / Seung, E. / Xu, L. / Rao, E. / Lord, D.M. / Wei, R.R. / Cortez-Retamozo, V. / Ospina, B. / Posternak, V. / Ulinski, G. ...Wu, L. / Seung, E. / Xu, L. / Rao, E. / Lord, D.M. / Wei, R.R. / Cortez-Retamozo, V. / Ospina, B. / Posternak, V. / Ulinski, G. / Piepenhagen, P. / Francesconi, E. / El Murr, N. / Beil, C. / Dabdoubi, T. / Cameron, B. / Bertrand, T. / Ferrari, P. / Pouzieux, S. / Lemoine, C. / Prades, C. / Park, A. / Qiu, H. / Song, Z. / Zhang, B. / Sun, F. / Chiron, M. / Rao, S. / Radosevic, K. / Zhi-yong, Y. / Nabel, G.J.
External linksTo Be Published / Search PubMed
MethodsX-ray diffraction
Resolution3.547 Å
Structure data

PDB-6o8d:
Anti-CD28xCD3 CODV Fab bound to CD28
Method: X-RAY DIFFRACTION / Resolution: 3.547 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Multispecific antibody / cross-over dual variable immunoglobin / multifunctional biotherapeutic format / bispecific property / CODV / T cell activation

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