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TitleCryogenic Electron Microscopy Reveals Dual-Inhibition Mechanisms and Explains the Differential Neutralization Potency of Two anti-CHIKV Antibodies
Journal, issue, pagesTo Be Published
Publish dateMar 29, 2024 (structure data deposition date)
AuthorsSu GC / Pintilie G / Galaz-Montoya JG / Jin J / Chiu W
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.3 - 4.8 Å
Structure data

EMDB-44337: Cryo-EM structure of Chikungunya virus in complex with Fab fragment of neutralizing antibody C9
Method: EM (single particle) / Resolution: 4.6 Å

EMDB-44340: Cryo-EM structure of Chikungunya virus in complex with Fab fragment of neutralizing antibody IM-CKV063
Method: EM (single particle) / Resolution: 4.8 Å

44423

9bbn

EMDB-44423, PDB-9bbn:
Cryo-EM structure of Chikungunya virus asymmetric unit with Fab C9
Method: EM (single particle) / Resolution: 3.3 Å

44547

9bhh

EMDB-44547, PDB-9bhh:
Cryo-EM structure of Chikungunya virus asymmetric unit with Fab IM-CKV063
Method: EM (single particle) / Resolution: 3.5 Å

Source
  • chikungunya virus
  • mus musculus (house mouse)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / CHIKV asymmetric unit with Fab C9 / VIRAL PROTEIN-IMMUNE SYSTEM complex / CHIKV / Fab IM-CKV063

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