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Structure paper

TitleStructure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes
Journal, issue, pagesChem, Vol. 5, Year 2019
Publish dateJul 10, 2019 (structure data deposition date)
AuthorsLa Sala, G. / Olieric, N. / Sharma, A.
External linksChem / Search PubMed
MethodsX-ray diffraction
Resolution1.52 - 1.801 Å
Structure data

PDB-6s8k:
Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

PDB-6s8l:
Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes
Method: X-RAY DIFFRACTION / Resolution: 1.801 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-PN6:
(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • bos taurus (domestic cattle)
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / Tubulin / Microtubules / Microtubule targeting agents / Cancer

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