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-Structure paper
Title | Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites |
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Journal, issue, pages | Chemical Science, Vol. 12, Page 3876-3884, Year 2021 |
Publish date | Mar 19, 2020 (structure data deposition date) |
![]() | Zhao, X.Z. / Kiselev, E. / Lountos, G.T. / Wang, W. / Tropea, J.E. / Needle, D. / Hilimire, T.A. / Schneekloth, J.S. / Waugh, D.S. / Pommier, Y. / Burke, T.R. |
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Methods | X-ray diffraction |
Resolution | 1.7 - 1.856 Å |
Structure data | ![]() PDB-6w7k: ![]() PDB-6w7l: |
Chemicals | ![]() ChemComp-TG7: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-TGV: |
Source |
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![]() | HYDROLASE/HYDROLASE Inhibitor / phosphodiesterase / inhibitor / cancer drug target / DNA BINDING PROTEIN / HYDROLASE-HYDROLASE Inhibitor complex |