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TitleStructural insights into protein splicing inhibition by platinum therapeutics as potential anti-microbials
Journal, issue, pagesTo be published
Publish dateFeb 3, 2016 (structure data deposition date)
AuthorsChan, H. / Pearson, S. / Green, C. / Li, Z. / Zhang, J. / Lippard, S. / Belfort, G. / Shekhtman, A. / Li, H.M. / Belfort, M.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.401 - 1.5 Å
Structure data

PDB-5i0a:
RecA mini intein in complex with cisplatin
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-5k08:
RecA mini intein-Zeise's salt complex
Method: X-RAY DIFFRACTION / Resolution: 1.401 Å

Chemicals

ChemComp-CPT:
Cisplatin / medication, chemotherapy*YM

ChemComp-TCE:
3,3',3''-phosphanetriyltripropanoic acid

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-ZPT:
Trichloro(ethene)platinate(II)

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsSPLICING / Inhibitor / cisplatin / intein / HYDROLASE / Zeise's salt / complex

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