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TitleSmall-Molecule Inhibitors of the m7G-RNA Writer METTL1
Journal, issue, pagesAcs Bio Med Chem Au, Year 2023
Publish dateMay 6, 2021 (structure data deposition date)
AuthorsNai, F. / Flores Espinoza, M.P. / Invernizzi, A. / Vargas-Rosales, P.A. / Bobileva, O. / Herok, M. / Caflisch, A.
External linksAcs Bio Med Chem Au / Search PubMed
MethodsX-ray diffraction
Resolution1.59 - 1.85 Å
Structure data

PDB-7ogj:
Crystal structure of human METTL1 in complex with SAH
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

PDB-7pl1:
Crystal structure of human METTL1 bound to Sinefungin
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-CL:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-SFG:
SINEFUNGIN

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / METTL1 / Complex / SAH / Methyltranferase

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