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TitleStructural basis of herpes simplex type 1 virus DNA polymerase holoenzyme in DNA replication and acyclovir inhibition and proof-reading
Journal, issue, pagesTo Be Published
Publish dateAug 24, 2024 (structure data deposition date)
AuthorsWu YQ / Chen XL / Jiang ZY / Li DY / Zhang ZY / Dong CJ
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.15 Å
Structure data

61289

9ja3

EMDB-61289, PDB-9ja3:
Herpes simplex virus type 1 polymerase machinery in complex with duplex DNA, acyclovir triphosphate and calcium ions
Method: EM (single particle) / Resolution: 3.15 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-AVP:
ACYCLOVIR TRIPHOSPHATE

Source
  • human herpesvirus 1 (strain 17)
  • synthetic construct (others)
KeywordsREPLICATION / Herpes simplex virus type 1 / HSV-1 / UL30 / UL42 / DNA replication holoenzyme / DNA replication machinery / acyclovir triphosphate / DNA / Calcium

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