タイトル | The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS |
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ジャーナル・号・ページ | Nat Commun, Vol. 15, Page 4012-, Year 2024 |
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掲載日 | 2022年4月29日 (構造データの登録日) |
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著者 | Wu, S. / Gabelli, S.B. / Sohn, J. |
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リンク | Nat Commun / PubMedで検索 |
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手法 | X線回折 |
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解像度 | 2.26 - 2.7 Å |
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構造データ | PDB-7uux: ATP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-7uxw: Structure of ATP and GTP bind to Cyclic GMP AMP synthase (cGAS) through Mg coordination 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å PDB-7uyq: Structure of GTP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å PDB-7uyz: Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG 手法: X-RAY DIFFRACTION / 解像度: 2.49 Å PDB-7uzr: Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-7v0w: Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2,5 )pA 手法: X-RAY DIFFRACTION / 解像度: 2.66 Å |
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化合物 | ChemComp-OKR: [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
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由来 | - mus musculus (ハツカネズミ)
- dna molecule (その他)
- synthetic construct (人工物)
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キーワード | Transferase/DNA / Transferase-DNA complex / Complex / ATP / GTP / Magnesium / IMMUNE SYSTEM / pppGpG / Manganese / 5 -pppG(2 / 5 )pA |
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