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Structure paper

TitleMechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC7
Journal, issue, pagesTo Be Published
Publish dateJul 18, 2024 (structure data deposition date)
AuthorsHilton J / Lin Y / Sefah E / Deme JC / Parker J / Langton MJ / Grabe M / Lea S / Newstead S / Mindell JA
External linksSearch PubMed
MethodsEM (single particle)
Resolution1.8 - 2.7 Å
Structure data

51097

9g6c

EMDB-51097, PDB-9g6c:
CLC7/OSTM1 complex with bound PIP2 lipid
Method: EM (single particle) / Resolution: 1.8 Å

51098

9g6d

EMDB-51098, PDB-9g6d:
CLC7/OSTM1 complex in the absence of PIP2 lipid.
Method: EM (single particle) / Resolution: 2.7 Å

51099

9g6e

EMDB-51099, PDB-9g6e:
CLC7(Y715C)/OSTM1 complex
Method: EM (single particle) / Resolution: 2.6 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

PDB-1iit:
GLUR0 LIGAND BINDING CORE COMPLEX WITH L-SERINE

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Lysosomal transporter / pH Regulation / Membrane Complex / Transporter

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