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Structure paper

TitleStructure-Guided Engineering of a Short-Chain Dehydrogenase LfSDR1 for Efficient Biosynthesis of (R)-9-(2-Hydroxypropyl)adenine, the Key Intermediate of Tenofovir
Journal, issue, pagesAdv. Synth. Catal., Year 2024
Publish dateFeb 9, 2024 (structure data deposition date)
AuthorsWang, Q. / Cong, L. / Guo, J. / Wang, J. / Han, X. / Zhang, W. / Liu, W. / Wei, H. / You, S.
External linksAdv. Synth. Catal. / Search PubMed
MethodsX-ray diffraction
Resolution1.54 - 2.22 Å
Structure data

PDB-8yai:
Crystal structure of glucose 1-dehydrogenase mutant1 from Limosilactobacillus fermentum
Method: X-RAY DIFFRACTION / Resolution: 2.13 Å

PDB-8yau:
Crystal structure of glucose 1-dehydrogenase mutant2 from Limosilactobacillus fermentum
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

PDB-8zax:
Crystal structure of a short-chain dehydrogenase from Lactobacillus fermentum with NADPH
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Source
  • limosilactobacillus fermentum (bacteria)
KeywordsHYDROLASE / glucose 1-dehydrogenase / short-chain dehydrogenase / Lactobacillus fermentum

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