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TitleBinding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 121, Page 5645-5652, Year 1999
Publish dateJul 29, 1998 (structure data deposition date)
AuthorsSchnell, J.R. / Ketchem, R.R. / Boger, D.L. / Chazin, W.J.
External linksJ. Am. Chem. Soc. / Search PubMed
MethodsNMR (solution)
Structure data

PDB-1dsi:
Solution structure of a duocarmycin sa-indole-alkylated dna dupleX
Method: SOLUTION NMR

Chemicals

ChemComp-DSI:
4-HYDROXY-6-(1H-INDOLE-2-CARBONYL)-8-METHYL-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER

KeywordsDNA / DEOXYRIBONUCLEIC ACID / DUOCARMYCIN / MINOR GROOVE BINDING / ANTITUMOR AGENT / LIGAND-DNA COMPLEX

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