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Structure paper

TitleFamoxadone and related inhibitors bind like methoxy acrylate inhibitors in the Qo site of the BC1 compl and fix the rieske iron-sulfur protein in a positio close to but distinct from that seen with stigmatellin and other "DISTAL" Qo inhibitors.
Journal, issue, pagesTo be Published
Publish dateDec 27, 2009 (structure data deposition date)
AuthorsHuang, L. / Berry, E.A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.76 - 3.06 Å
Structure data

PDB-3l71:
Cytochrome BC1 complex from chicken with azoxystrobin bound
Method: X-RAY DIFFRACTION / Resolution: 2.84 Å

PDB-3l72:
Chicken cytochrome BC1 complex with kresoxim-I-dimethyl bound
Method: X-RAY DIFFRACTION / Resolution: 3.06 Å

PDB-3l73:
Cytochrome BC1 complex from chicken with triazolone inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.04 Å

PDB-3l74:
Cytochrome BC1 complex from chicken with famoxadone bound
Method: X-RAY DIFFRACTION / Resolution: 2.76 Å

Chemicals

ChemComp-PEE:
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / DOPE, phospholipid*YM

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-AZO:
METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE

ChemComp-UQ:
Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer

ChemComp-GOL:
GLYCEROL

ChemComp-HEC:
HEME C

ChemComp-CDL:
CARDIOLIPIN / phospholipid*YM

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

ChemComp-HOH:
WATER

ChemComp-IKR:
methyl (2E)-{2-[(4-iodo-2,5-dimethylphenoxy)methyl]phenyl}(methoxyimino)ethanoate

ChemComp-JZZ:
4-[7-(3,3-dimethylbut-1-yn-1-yl)naphthalen-1-yl]-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one


ChemComp, No image

ChemComp-UNL:
Unknown ligand

ChemComp-FMX:
FAMOXADONE

ChemComp-AZI:
AZIDE ION

Source
  • gallus gallus (chicken)
KeywordsOXIDOREDUCTASE / CYTOCHROME BC1 / MEMBRANE PROTEIN / HEME PROTEIN / RIESKE IRON SULFUR PROTEIN / CYTOCHROME B / CYTOCHROME C1 / COMPLEX III / MITOCHONDRIAL PROCESSING PROTEIN / UBIQUINONE / AZOXYSTROBIN OXIDOREDUCTASE / REDOX ENZYME RESPIRATORY CHAIN / ELECTRON TRANSPORT / HEME / INNER MEMBRANE / MEMBRANE / STROBILURINS BINDING / MITOCHONDRION / TRANSMEMBRANE / STIGMATELLIN / IRON / MITOCHONDRIAL INNER MEMBRANE / RESPIRATORY CHAIN / IRON-SULFUR / TRANSIT PEPTIDE / Metal-binding / Mitochondrion inner membrane / Transport / Disulfide bond

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