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TitleCryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in Saposin A nanodisc bound to GABA and Etomidate in the long-lived symmetric desensitised state
Journal, issue, pagesTo Be Published
Publish dateMay 23, 2024 (structure data deposition date)
AuthorsMihaylov DB / Malinauskas T / Aricescu AR
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.6 Å
Structure data

50400

9fgg

EMDB-50400, PDB-9fgg:
Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in Saposin A nanodisc bound to GABA and Etomidate in the long-lived symmetric desensitised state
Method: EM (single particle) / Resolution: 2.6 Å

Chemicals

ChemComp-PIO:
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate

ChemComp-D10:
DECANE

ChemComp-CL:
Unknown entry

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID

ChemComp-V8D:
Etomidate

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-R16:
HEXADECANE

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / GABA / neurotransmission / gating cycle / time-resolved cryo-EM

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