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TitleDual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria
Journal, issue, pagesACS Medicinal Chemistry Letters, Vol. 12, Page 1116-1123, Year 2021
Publish dateMar 17, 2021 (structure data deposition date)
AuthorsDing, J. / Gumpena, R. / Boily, M.O. / Caron, A. / Chong, O. / Cox, J.H. / Dumais, V. / Gaudreault, S. / Graff, A.H. / King, A. ...Ding, J. / Gumpena, R. / Boily, M.O. / Caron, A. / Chong, O. / Cox, J.H. / Dumais, V. / Gaudreault, S. / Graff, A.H. / King, A. / Knight, J. / Oballa, R. / Surendradoss, J. / Tang, T. / Wu, J. / Lowther, W.T. / Powell, D.A.
External linksACS Medicinal Chemistry Letters / Search PubMed
MethodsX-ray diffraction
Resolution2.07 - 2.5 Å
Structure data

PDB-7m2n:
Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-7m2o:
Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

Chemicals

ChemComp-NAI:
1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-YOJ:
5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid

ChemComp-HOH:
WATER

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE

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